Comparison of the Virtual Biopsies of a Nodular Basal Cell Carcinoma and an Actinic Keratosis: Morphological, Cellular and Collagen Analyses

Frederick H. Silver, Ruchit G. Shah, Michael Richard and Dominick Benedetto

Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
OptoVibronex LLC, Mt. Bethel, PA, USA
Graduate Program in Biomedical Engineering, Rutgers, the State University of New Jersey, Piscataway, USA
Neigel Center for Cosmetic and Laser Surgery, Floram Park, NJ, USA
Center for Advanced Eye Care, Vero Beach, FL, USA

^*Correspondance to: Frederick H. Silver 

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Abstract:

Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar, a basal cell carcinoma and an actinic keratosis non-invasively and non-destructively.It is concluded that enhanced VOCT images of surface roughness and lesion morphology in combination with estimates of cellular and collagen content may assist the clinician in better characterizing different skin lesions prior to excision. The use of VOCT in the physician’s office will assist the surgeon in preoperative planning and facilitate patient treatment that will benefit both the doctor and patient.

Keywords:

Actinic keratosis; Mechanical properties; Stiffness; Modulus; Collagen; Extracellular matrix; Keratinocytes

Cite the Article:

Silver FH, Shah RG, Richard M, Benedetto D. Comparison of the Virtual Biopsies of a Nodular Basal Cell Carcinoma and an Actinic Keratosis: Morphological, Cellular and Collagen Analyses. Clin Oncol. 2019; 4: 1588.