Promoter Polymorphism in the Interleukin-10 Confers an Increased Risk of DLBCL in Chinese

Bao Song, Yuhong Liu, Chuanxi Wang and Jie Liu

Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital & Institute, Shandong Academy of Medical Sciences, China
Department of Clinical Laboratory, Shandong Cancer Hospital & Institute, China
Department of Oncology, Shandong Provincial Hospital, China4Department of Oncology, Shandong Cancer Hospital & Institute, Shandong Academy of Medical Sciences, China

^*Correspondance to: Bao Song 

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Abstract:

Findings suggest that genetic polymorphisms in cytokine genes are associated with an increased risk of Non-Hodgkin Lymphoma (NHL) in Caucasians. This study was designed to assess whether single nucleotide polymorphisms in IL-10 promoter play a role in predisposing individuals to NHL in Chinese populations. We genotyped four SNPs in the distal and proximal IL-10 promoter (IL-10 -3575T/A, IL-10 -1082A/G,-819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis. We conducted this study in 512 NHL cases and 500 age- and sex-matched healthy controls. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the association between individual SNP and haplotypes with non-Hodgkin lymphoma overall and two well-defined subtypes [Diffuse Large B-Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL)]. No significant correlation of IL-10-3575T/A, IL-10-1082A/G,-819T/C and -592A/C polymorphisms to risk of NHL overall. When analyses by subtype, the -1082 AG genotypes and G alleles were associated with a significantly increased risk of DLBCL as compared with the -1082 AA genotype and A alleles (OR=1.64, 95% CI 1.06~2.54, P=0.025 for AG; OR=1.57, 95% CI 1.06-2.31, P=0.023 for G allele). Haplotype analyses revealed three common haplotype (TATA, TACC and AGCC), there was no significant differences in the estimated frequencies of haplotypes between overall NHL or subtypes and controls. Our results suggest that IL-10 promoter -1082 SNP might be a risk factor of DLBCL development in Chinese populations.

Keywords:

Interleukin-10; Non-Hodgkin lymphoma; Polymorphisms; Diffuse large B-cell lymphoma; Haplotype

Cite the Article:

Song B, Liu Y, Wang C, Liu J. Promoter Polymorphism in the Interleukin-10 Confers an Increased Risk of DLBCL in Chinese. Clin Oncol. 2019; 4: 1566.