Is Polycystic Ovarian Syndrome a Risk Factor for Urinary Stone Disease?

Xinguo Zhu, Ikbal Kaygusuz, Ayla Eser, Mehmet Erol Yildirim, Ersin Çimentepe, Ebru Yüce and Kadir Çetinkaya

Department of Obstetrics and Gynecology, Etlik Lokman Hekim Hospital, China

^*Correspondance to: Xinguo Zhu 

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Abstract:

Urinary stone disease is a multi factorial disorder and a complex process influenced by both intrinsic and environmental factors with an approximate prevalence of 1% to 15% worldwide that varies depending on elements such as age, sex, race, and genetic factors. In animal and human studies, testosterone has been shown to increase the formation of urinary stones. This suggests that sex hormones are involved in the pathogenesis of stone disease. Hyperandrogenism, the main feature of Poly Cystic Ovary Syndrome (PCOS), may trigger the urinary stone formation besides hirsutism, alopecia and acne. The present study was performed to investigate whether patients with PCOS were at risk in terms of urinary system stone disease. Forty patients with PCOS and 40 healthy controls were included in the study, after exclusions the study ended up with 38 patients (PCOS group n=23, control group n=15). 24-hr urinary composition, biochemical and hormonal levels were analyzed. 24-hr excretion of oxalate was statistically significantly higher in the PCOS subjects than control group. Patients with PCOS had higher urinary uric acid and lower citrate levels than control subjects. There was no difference for urinary calcium levels between the PCOS and control groups. PCOS may trigger the urinary stone disease.

Keywords:

Urinary stone disease; Polycystic ovary syndrome; Urinary oxalate; Urinary uric acid; Urinary citrate; Urinary calcium

Cite the Article:

Zhu X, Kaygusuz I, Eser A, Yildirim ME, Çimentepe E, Yüce E, et al. Is Polycystic Ovarian Syndrome a Risk Factor for Urinary Stone Disease? Clin Oncol. 2018; 3: 1443.