Prognostic Factors in Leptomeningeal Metastasis

Yasemin Benderli Cihan and Aynur Aytekin

Department of Radiation Oncology, Kayseri Education and Research Hospital, Turkey

^*Correspondance to: Yasemin Benderli Cihan 

 PDF  Full Text Research Article | Open Access

Abstract:

Objective: To investigate prognostic factors this can be effective in survival of patients with Leptomeningeal Metastases (LM) from solid tumors.Materials and
Methods: Between 2005-2015, in the Radiation Oncology Department of Kayseri Education and Research Hospital, 16 patients with leptomeningeal metastasis from solid tumors were evaluated. Retrospective review of patient medical records was conducted to gather demographics, treatment patterns, and clinical outcomes.Results: A 8 patients with breast cancer; 4 patients with lung cancer; 4 patients with prostate cancer were diagnosed as a primary cause of disease. The mean age at the time of diagnosis was 58.9. Of all patients, 87.5% had ECOG 2 and 3; 43.8% had comorbidity; 56.3% had two organ metastases; 43.8% had parenchymal brain metastases. The most frequent location for leptomeningeal metastasis was brain. All patients received palliative Radio Therapy (RT) and 18% of the patients received chemotherapy following RT. The median overall survival after LM was 9.4 month and 1 year overall survival was 40%. Factor affecting overall survival was age ≤65 years (p = 0.046), female gender (p = 0.046), comorbidity (p = 0.039) and radiotherapy fraction dose schedules (p = 0.002). According to univariate and multivariate analysis was a not significant factor affecting overall survival.Conclusion: In this study, LM was seen mostly in breast cancers and lung cancer patients’ survival was found shorter. Age, gender and accompanying comorbidity was found to be effective in prognosis.

Keywords:

Leptomeningeal metastasis; Solid tumor; Radiotherapy; Prognostic factors

Cite the Article:

Cihan YB, Aytekin A. Prognostic Factors in Leptomeningeal Metastasis. Clin Oncol. 2018; 3: 1429.