Diagnostic Accuracy of Technetium-99m -Octreotide in Imaging Neuroendocrine, Our Experience with Literature Review

Naima Al Bulushi, Badriya Al Saqri, Marwa Al Amri, Aymen Al Hadidi, Hafidh Al Jahdami, Mohammed Al Zadjali and Mimouna Al Risi

Royal Hospital, Ministry of Health, Oman
Oman Medical Specialty Board (OMSB), Oman
Medical students, College of Medicine, Sultan Qaboos University Hospital, Oman

^*Correspondance to: Naima Al Bulushi 

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Abstract:

Purpose: The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using Technetium-99m - Octreotide in imaging Neuroendocrine tumors (NETs).Materials and
Methods: A total of 58 patients with Technetium-99m -Octreotide (Tc-99m- OCT) were identified in our database, from January 2013 until December 2016. 41 patients (age range of 15-75 year) meet our inclusion criteria namely; histopathology proven neuroendocrine tumors, Technetium-99m -Octreotide scan, CT, MRI or both done in our institute for correlation.Results: 23 patients had true positive Tc-99m– OCT scan. In addition to the primary tumors the Octeriotide scan revealed metastasis in the lung, liver and retroperitoneal lymph nodes. The smallest lesion detected on Octreotide scan was a 4-mm pulmonary nodule, that was missed on lung window CT scan. The Tc-99m– OCT had 17 true negative, one false negative and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative and one false positive. The overall sensitivity, specificity, accuracy, positive and negative predictive values of Tc-99m– OCT scan were; 96%, 100%, 97%, 100% and 94% respectively. Whereas those of CT and MRI were; 78%, 94%, 85%, 94% and 77%, respectively.Conclusion: The overall diagnostic accuracy of Technetium-99m-Octreotide is high. In addition to the conventional radiological investigations, Tc-99m-OCT scan is a mandate for better and accurate staging of patients with NETs.

Keywords:

Neuroendocrine tumors; Somatostatin; Technetium-99m; Indium-111; Octreotide; Gallium-68

Cite the Article:

Al Bulushi N, Al Saqri B, Al Amri M, Al Hadidi A, Al Jahdami H, Al Zadjali M, et al. Diagnostic Accuracy of Technetium-99m -Octreotide in Imaging Neuroendocrine, Our Experience with Literature Review. Clin Oncol. 2017; 2: 1361.