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- Neoadjuvant Therapy
- Chemoprevention
- Lung Cancers
- Gynecological Cancers
- Breast Cancer
- Immunotherapy
- Immunology
- Radiological Techniques and Scans
Abstract
Citation: Clin Oncol. 2017;2(1):1360.DOI: 10.25107/2474-1663.1360
Functional Polymorphisms in the Cyclooxygenase 2 (COX-2) Gene And Risk of Breast Cancer in North Indian Population
Satya N Das, Rekha Kataria and Rajinder Parshad
Departments of Biotechnology, All India Institute of Medical Sciences, India
Departments of Surgical Discipline, All India Institute of Medical Sciences, India
*Correspondance to: Satya N Das
PDF Full Text Research Article | Open Access
Abstract:
Introduction: COX-2 is a rate limiting enzyme involved in carcinogenesis, immunosuppression, inhibition of apoptosis, angiogenesis, tumor cell invasion and metastasis. Enhanced expression of COX-2 has been observed in several forms of cancer such as gastric cancer, breast cancer and esophageal cancer. Single nucleotide polymorphisms (SNPs) in the COX-2 promoter might contribute to differential COX-2 expression and subsequent interindividual variation in susceptibility to cancer. Hence, we assessed the association of COX-2 promoter Single Nucleotide Polymorphisms (SNPs) (-1195G/A, -765G/C and 8473C/T) with breast cancer.Materials and
Method: Genotyping was performed in 82 biopsy proven patients and 49 (34 in case of -765) age and sex-matched healthy control subjects by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis.Result: Logistic regression analyses revealed that no overall significant associations were detected in the single-locus analysis between the -765, -1195 and 8473 polymorphisms of COX-2 and the risk of breast cancer. However, a significantly increased risk was associated with the combined genotypes containing more than 3 variant alleles (OR= 2.05, 95% CI = 0.816-5.17) compared with the combined genotypes with 0-3 variant alleles. Haplotype frequency analysis suggest that A-1195G765T8473 was more prevalent in patients when compared with the normals whereas G-1195C-765C8473, A-1195C-765C8473 and G-1195G-765C8473 were more in normals as compared to patients though the results were not statistically significant. It appears that A-1195G-765T8473 may be related to susceptibility while G-1195C-765C8473, A-1195C-765C8473 and G-1195G-765C8473 may be related to protection in breast cancer.Conclusion: These findings indicate that these three variants in the regulatory regions of COX-2 may contribute to the etiology of breast cancer.
Keywords:
COX-2; SNP; Breast cancer; North Indian
Cite the Article:
Das SN, Kataria R, Parshad R. Functional Polymorphisms in the Cyclooxygenase 2 (COX-2) Gene And Risk of Breast Cancer in North Indian Population. Clin Oncol. 2017; 2: 1360.