5FU Synergistically Inhibits MCF-7 in Combination with Methylglyoxal

Sonali Ghosh, Aparajita Pal and Manju Ray

Department of Biophysics, Bose institute, Centenary Building, India
Department of Biophysics, GLA University, Mathura, India

^*Correspondance to: Manju Ray 

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Abstract:

Reduction of toxicity due to uses of conventional chemotherapeutics drugs is a major challenge in cancer treatment. With this aim we combined 5FU, a widely used chemotherapeutic drug and methylglyoxal (MG), a non toxic anticancer agent in breast cancer cell line, MCF-7. Treatment with 5-FU in combination with MG on MCF 7 cells exert synergistic effects in proliferation and destruction of those cells as determined by MTT, clonogenic assay and scratch wound healing assay. Results clearly showed that 5FU is more effective at lower doses in presence of MG. Taken together, our preliminary results revealed that MG can be used in combination therapy to reduce the concentration of toxic 5-FU against breast cancer cell.

Keywords:

Methylglyoxal; 5Fluoro Uracil; Cancer; MCF-7

Cite the Article:

Ghosh S, Pal A, Ray M. 5FU Synergistically Inhibits MCF-7 in Combination with Methylglyoxal. Clin Oncol. 2017; 2: 1353.