Bacteriophages in Cancer Biology and Therapies

Swapnil Ganesh Sanmukh and Sérgio Luis Felisbino

Laboratory of Extracellular Matrix Biology, Department of Morphology, Institute of Biosciences Botucatu, Sao Paulo State University, Sao Paulo, Brazil

^*Correspondance to: S�rgio Luis Felisbino 

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Abstract:

Cancer is one of the most challenging disease because of its unique individual identity and nonuniform progression within the same host. This confronting situation demands individual treatment therapies namely “personalized medicine”. Besides the improved success of available cancer treatments in the majority of cancer cases, for many of them, they have proved ineffective as the cancer cells evolve with treatment and show adaptive behavior. Bacteriophage (phage) therapy and phage-based therapies have gained special attention as a promising approach for cancer therapy beyond their action against multi-drug resistant bacterial infections. Considering the remarkable development in the phage research, mainly in biomedical sciences, molecular biology and nanobiotechnology; until now few conceptual reports about cancer and bacteriophage interactions and/or detailed study for phage-based therapies in cancer are available. These kind of information are valuable for reducing prejudices and to fundament discussions at regulatory agencies and departments for its safe use in humans for cancer therapy. Here we have tried to summarize the important works carried out about phage-cancer research and provide updated information about its ongoing progress and possible future perspectives.

Keywords:

Cancer; Bacteriophage; Nanobiotechnology; Regulatory agencies

Cite the Article:

Sanmukh SG, Felisbino SL. Bacteriophages in Cancer Biology and Therapies. Clin Oncol. 2017; 2: 1295.