The Theragnostic Relevance of DNA Methylation Analysis in Cancer

Tibor Hortobágyi, Renáta Szabó, Balázs Murnyák

Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Hungary

^*Correspondance to: Tibor Hortob�gyi 

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Abstract:

pigenetics has become a focus of interest in tumour research, also because it has theragnostic implications. DNA methylation is frequently observed epigenetic alteration in cancer. Impaired transcription of genes caused by DNA methylation is associated with tumorigenesis and malignant transformation. To date numerous methylated genes were identified as candidate biomarkers by means of high-throughput molecular techniques in glioblastoma, lung, breast, and colon cancer. We review and assess the current DNA methylation analysis methods with emphasis on their relevance to biomarker research and clinical utilization. Although not yet in the routine diagnostic protocols, further research and technical advance may render DNA methylation analysis an integral diagnostic tool to further the cause of personalized medicine.

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Cite the Article:

Hortobágyi T, Szabó R, Murnyák B. The Theragnostic Relevance of DNA Methylation Analysis in Cancer. Clin Oncol. 2017; 2: 1289.