Rare Breast Myoepithelial Carcinoma with a Distinctive Genetic Profiling Study

Kerolos Abadeer, Judith S. Kaur, Mohd E.M. Ibrahim and Aziza Nassar

Division of Nephrology and Hypertension, USA
Division of Hematology and Oncology and Cancer Center and Breast Clinic, USA
Department of Laboratory Medicine and Pathology, Mayo Clinic, USA
Division of Pathology, Massey Cancer Center/VCU, USA

^*Correspondance to: Aziza Nassar 

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Abstract:

We describe a 74-year-old woman with no family history of breast cancer who presented with a high-grade myoepithelial carcinoma. Diagnosis was supported by immunohistochemical staining for both epithelial (ie, keratin) and myoepithelial (eg., p63, S-100, actin) differentiation. Because the patient reported that her family had an extensive history of neoplasm, a genetic study was ordered. To our knowledge, this is the first case to be reported in the literature with a complete genomic profiling study in which a 4-gene alteration has been detected. Molecular genetics profiling of the tumor using a genetic profile showed a genetic alteration in NF1 (L494fs*4), IRS2 amplification, RB1 loss, and TP53 (Y107D). The patient underwent lumpectomy with sentinel lymph node biopsy and chemotherapy treatment with carboplatin and taxol. She is alive and free of disease.

Keywords:

Breast; Genetics; Genomic profiling; Immunohistochemistry; Metaplastic carcinoma; Myoepithelial carcinoma; p63

Cite the Article:

Abadeer K, Kaur JS, Ibrahim MEM, Nassar A. Rare Breast Myoepithelial Carcinoma with a Distinctive Genetic Profiling Study. Clin Oncol. 2017; 2: 1215.