Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Colorectal Cancer
  •  Hormone Therapy
  •  Sarcomas
  •  Chemotherapy and Radiotherapy
  •  Lung Cancers
  •  Radiation Oncology
  •  Paediatric Cancers
  •  Endometrial Cancer

Abstract

Citation: Clin Oncol. 2017;2(1):1199.DOI: 10.25107/2474-1663.1199

B7 Gene Family: Promising Immunotherapeutic Checkpoint in Cancers

Yinxin Zhu, Jing Shen and Zhangang Xiao

Department of Gastroenterology, Soochow University, China
Department of Pharmacology, Southwest Medical University, China

*Correspondance to: Zhangang Xiao 

 PDF  Full Text Short Communication | Open Access

Abstract:

The B7 gene family plays critical roles in regulating adaptive cellular immunity by either costimulating or co-inhibiting T cell functions. And the oncogenic roles of B7 family have already been identified in various cancers, with the immune checkpoint inhibitors of PD-L1/PD-1and CTLA-4/B7 being successfully applied in cancer treatment.

Keywords:

Cite the Article:

Zhu Y, Shen J, Xiao Z. B7 Gene Family: Promising Immunotherapeutic Checkpoint in Cancers. Clin Oncol. 2017; 2: 1199.

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