B7 Gene Family: Promising Immunotherapeutic Checkpoint in Cancers

Yinxin Zhu, Jing Shen and Zhangang Xiao

Department of Gastroenterology, Soochow University, China
Department of Pharmacology, Southwest Medical University, China

^*Correspondance to: Zhangang Xiao 

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Abstract:

The B₇ gene family plays critical roles in regulating adaptive cellular immunity by either costimulating or co-inhibiting T cell functions. And the oncogenic roles of B7 family have already been identified in various cancers, with the immune checkpoint inhibitors of PD-L1/PD-1and CTLA-4/B7 being successfully applied in cancer treatment.

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Cite the Article:

Zhu Y, Shen J, Xiao Z. B7 Gene Family: Promising Immunotherapeutic Checkpoint in Cancers. Clin Oncol. 2017; 2: 1199.