Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Pancreatic Cancer
  •  Immunotherapy
  •  Lung Cancers
  •  Bladder Cancer
  •  Central Nervous System Tumors
  •  Targeted Therapy
  •  Paediatric Cancers
  •  Brain and Spinal Cord Cancer


Citation: Clin Oncol. 2017;2(1):1186.DOI: 10.25107/2474-1663.1186

Valproic Acid in Patients with Glioma: A Small Review

Bernardo Cacho-Díaz and Nydia A. Lorenzana-Mendoza

Neuroscience Unit, Instituto Nacional de Cancerología, Mexico

*Correspondance to: Bernardo Cacho-Diaz 

 PDF  Full Text Mini Review | Open Access


Seizures are a well-known and feared manifestation of brain tumors. To some extent, the association between gliomas and the prevalence of seizures correlates inversely with histologic tumor grade. The standard therapy for glioma patients is based on maximal safe resection, followed by temozolomide and radiotherapy. Preclinical studies have proposed a modulatory role of the antiepileptic drug Valproic Acid (VPA) on the efficacy of this treatment increasing overall survival. VPA has shown to: 1) inhibit histone deacetylase increasing the sensitivity of tumor cells to radiation; and 2) have a cytotoxic and proapoptotic role on glioma cells inducing autophagy. We will address the information from studies concerning the use of VPA in patients with glioma.


Cite the Article:

Cacho-Díaz B, Lorenzana-Mendoza NA. Valproic Acid in Patients with Glioma: A Small Review. Clin Oncol. 2017; 2: 1186.

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