Valproic Acid in Patients with Glioma: A Small Review

Bernardo Cacho-Díaz and Nydia A. Lorenzana-Mendoza

Neuroscience Unit, Instituto Nacional de Cancerología, Mexico

^*Correspondance to: Bernardo Cacho-Diaz 

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Abstract:

Seizures are a well-known and feared manifestation of brain tumors. To some extent, the association between gliomas and the prevalence of seizures correlates inversely with histologic tumor grade. The standard therapy for glioma patients is based on maximal safe resection, followed by temozolomide and radiotherapy. Preclinical studies have proposed a modulatory role of the antiepileptic drug Valproic Acid (VPA) on the efficacy of this treatment increasing overall survival. VPA has shown to: 1) inhibit histone deacetylase increasing the sensitivity of tumor cells to radiation; and 2) have a cytotoxic and proapoptotic role on glioma cells inducing autophagy. We will address the information from studies concerning the use of VPA in patients with glioma.

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Cite the Article:

Cacho-Díaz B, Lorenzana-Mendoza NA. Valproic Acid in Patients with Glioma: A Small Review. Clin Oncol. 2017; 2: 1186.