Intracranial Dural Marginal Zone Lymphoma: A Case Report

Ahmed Gilani, Khurram Shafique, Jordan Iordanou, Ali Sadr, Charles Shao and Jinli Liu

Department of Pathology, Kings County Hospital Center, USA
SUNY Downstate School of Medicine, USA
Department of Neurosurgery, Kings County Hospital, USA

^*Correspondance to: Ahmed Gilani 

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Abstract:

We present a case of low grade Marginal Zone Lymphoma (MZL) presenting as a dural mass in a 21 year old woman. The patient presented with symptoms of raised intracranial pressure. Imaging findings were suggestive of meningioma. Histological analysis showed proliferation of CD20 positive small lymphoid cells forming nodules that were reminiscent of lymphoid follicles with attenuated germinal centers. In between the follicles, cells with plasmacytic differentiation were seen, which were CD138 positive and showed kappa light chain restriction by immunohistochemistry. Ki 67 proliferation index was 20-30%. The patient’s symptoms were alleviated after the surgery and the patient remains disease free more than two yearsafter resection. This case illustrates that although rare, Extra Nodal MZL should be considered in the differential diagnosis of a dura-based mass that fails to show typical meningioma morphology.

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Cite the Article:

Gilani A, Shafique K, Iordanou J, Sadr A, Shao C, Liu J. Intracranial Dural Marginal Zone Lymphoma: A Case Report. Clin Oncol. 2016; 1: 1145.