Hepatocellular Carcinoma - Review of Treatment Options with Percutaneous Ablative Therapies

Jessica Goldman, Marc Solomon and Sohail Contractor

Department of Radiology, New Jersey Medical School, USA

^*Correspondance to: Sohail Contractor 

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Abstract:

Hepatocellular carcinoma is a cause of significant morbidity and mortality with many risk factors contributing to its development. The underlying risk factors have a geographic distribution with alcohol and hepatitis C being the predominant factors in the western world and hepatitis B in the eastern world. Diagnosis is based on classic imaging features on a contrast enhanced CT or MRI scan. Pathological features vary with some tumors displaying aggressive behavior with vascular invasion and metastatic disease. Treatment options for cure include surgical resection and transplantation depending upon underlying liver function. Non operative treatments have started to gain more acceptance with percutaneous thermal based ablative modalities, including radiofrequency and microwave ablation. Results of ablation are comparable to those of surgical resection, especially for smaller lesions. Other treatment options include transcatheter based embolic treatments and an oral multikinase inhibitor, Sorafenib.

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Cite the Article:

Goldman J, Solomon M, Contractor S. Hepatocellular Carcinoma - Review of Treatment Options with Percutaneous Ablative Therapies. Clin Oncol. 2016; 1: 1107.