Splenic Marginal Zone Lymphoma with Concurrent Myelofibrosis: A Case Report

Slonim LB, Geller M, Donovan V and Harris J

Departments of Pathology, Winthrop-University Hospital, USA
Departments of Hematotology/Oncology, Winthrop-University Hospital, USA

^*Correspondance to: Liron Barnea Slonim 

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Abstract:

Myelofibrosis associated with lymphoid neoplasms is a rare occurrence with the exception of hairy cell leukemia. Its incidence in splenic marginal zone lymphoma, as we report in this article, has only been reported once in the past. We report the case of a 62 year old male with splenic marginal zone lymphoma and concurrent myelofibrosis. The diagnosis of splenic marginal zone lymphoma was achieved by a combination of clinical, morphological, and immunohistochemical findings. Increased reticulin staining of the bone marrow, cytopenias and macrocytes on peripheral blood smear supported the diagnosis of myelofibrosis. Features of primary myelofibrosis and other myelodysplastic features including associated genetic mutations were absent. Further investigation of the association between splenic marginal zone lymphoma and concurrent myelofibrosis may assist in future identification of its effect on disease course and overall prognosis, possibly playing a role in risk stratification and personalized therapy.

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Cite the Article:

Slonim LB, Geller M, Donovan V, Harris J. Splenic Marginal Zone Lymphoma with Concurrent Myelofibrosis: A Case Report. Clin Oncol. 2016; 1: 1090.