
Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Thoracic Oncology
- General Oncology
- Urological Cancers
- Sarcomas
- Prostate Cancer
- Haemato-Oncology
- Immunology
- Paediatric Cancers
Abstract
Citation: Clin Oncol. 2016;1(1):1081.DOI: 10.25107/2474-1663-v1-id1081
Outcome of Pediatric Patients with Low-Grade Astrocytoma of the Brain and Spinal Cord
Taneva M and Johnston DL
Division of Pediatric Hematology/Oncology, Children’s Hospital of Eastern Ontario, Canada
*Correspondance to: Donna Johnston
PDF Full Text Research Article | Open Access
Abstract:
Background: Low-grade astrocytomas are the most common pediatric central nervous system tumours. They can occur anywhere in the central nervous system and are often challenging to treat.
Methods: A retrospective review to compare the response to therapy for spinal cord astrocytomas to that of brain astrocytomas.
Results: Five patients had low-grade spinal cord astrocytoma and 43 had low-grade brain astrocytoma. One spinal cord and 16 brain patients underwent complete resection, and 2 and 20, respectively, partial resection. Of the 56% total patients with a partial resection, 31.8% and 4.5% received adjuvant chemotherapy and radiotherapy, respectively. 14% of all patients received chemotherapy, without resection. Three patients with spinal cord tumours underwent subtotal resection/biopsy followed by chemotherapy. They showed a mean tumour decrease of 36.9%, and none relapsed. The remaining patients showed tumour progression which responded to chemotherapy. Ten brain tumour patients received chemotherapy and 4 received radiation. Tumour size decreased by 44.5% with surgery/adjuvant therapy, and 27.1% with adjuvant therapy alone. Ten patients relapsed at a mean of 9.6 months. Those treated underwent resection (n=3) or adjuvant therapy (n=5) and 4 relapsed again. Conclusions: All patients with low-grade spinal cord astrocytomas responded to chemotherapy and none received radiation while 81.8% of those with brain astrocytoma responded to adjuvant therapy including radiation.
Keywords:
Low-grade astrocytoma; Chemotherapy; Therapy response
Cite the Article:
Taneva M, Johnston DL. Outcome of Pediatric Patients with Low-Grade Astrocytoma of the Brain and Spinal Cord. Clin Oncol. 2016; 1: 1081.