Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Lung Cancers
  •  Leukemia
  •  Melanoma/Skin Cancer
  •  Palliative Care
  •  Lymphoma
  •  General Oncology
  •  Carcinomas
  •  Gastrointestinal Cancer

Abstract

Citation: Clin Oncol. 2016;1(1):1081.DOI: 10.25107/2474-1663.1081

Outcome of Pediatric Patients with Low-Grade Astrocytoma of the Brain and Spinal Cord

Taneva M and Johnston DL


Division of Pediatric Hematology/Oncology, Children’s Hospital of Eastern Ontario, Canada

*Correspondance to: Donna Johnston 

 PDF  Full Text Research Article | Open Access

Abstract:

Background: Low-grade astrocytomas are the most common pediatric central nervous system tumours. They can occur anywhere in the central nervous system and are often challenging to treat.
Methods: A retrospective review to compare the response to therapy for spinal cord astrocytomas to that of brain astrocytomas.
Results: Five patients had low-grade spinal cord astrocytoma and 43 had low-grade brain astrocytoma. One spinal cord and 16 brain patients underwent complete resection, and 2 and 20, respectively, partial resection. Of the 56% total patients with a partial resection, 31.8% and 4.5% received adjuvant chemotherapy and radiotherapy, respectively. 14% of all patients received chemotherapy, without resection. Three patients with spinal cord tumours underwent subtotal resection/biopsy followed by chemotherapy. They showed a mean tumour decrease of 36.9%, and none relapsed. The remaining patients showed tumour progression which responded to chemotherapy. Ten brain tumour patients received chemotherapy and 4 received radiation. Tumour size decreased by 44.5% with surgery/adjuvant therapy, and 27.1% with adjuvant therapy alone. Ten patients relapsed at a mean of 9.6 months. Those treated underwent resection (n=3) or adjuvant therapy (n=5) and 4 relapsed again. Conclusions: All patients with low-grade spinal cord astrocytomas responded to chemotherapy and none received radiation while 81.8% of those with brain astrocytoma responded to adjuvant therapy including radiation.

Keywords:

Low-grade astrocytoma; Chemotherapy; Therapy response

Cite the Article:

Taneva M, Johnston DL. Outcome of Pediatric Patients with Low-Grade Astrocytoma of the Brain and Spinal Cord. Clin Oncol. 2016; 1: 1081.

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