Prognostic and Predictive Values of MicroRNAs in Pancreatic Cancer

Ghasemi F, Shahid Sales S, Hassanian SM and Avan A

Department of Modern Sciences and Technologies School of Medicine Molecular Medicine Group, Mashhad University of Medical Sciences, Iran
Department of Modern Sciences and Technologies School of Medicine Cancer Research Center; Mashhad University of Medical Sciences, Iran
Department of Biochemistry of Nutrition research center; School of Medicine, Mashhad University of Medical Sciences, Iran
Department of Modern Sciences and Technologies School of Medicine Microanatomy Research Center, Mashhad University of Medical Sciences, Iran

^*Correspondance to: Amir Avan 

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Abstract:

MicroRNAs (miRNAs) are small and none coding RNA that has been shown to be involved in multiple cellular processes including cell proliferation, apoptosis, survival, invasion, metastasis, and chemotherapeutic resistance of pancreatic cancer. There is growing body of evidence showing the dysregulation of some miRNA in PDAC, suggesting their values as prognostic and predictive biomarker. In particular it has been shown that miR-486-5p and miR-938 can discriminate PDAC patients from healthy individuals and those with chronic pancreatitis. Moreover, they suggested the diagnostic value of miR-486-5p for the detection of PDAC patients, compared to CA 19-9. In turn several miRNAs have emerged as therapeutic targets, including let-7, miR-29a, miR-17-5p, miR-365, miR-181b, miR-21, miR-221 and miR-96, which have been reported to be involved in chemotherapy resistance. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC as diagnostic and prognostic marker in PDAC.

Keywords:

MicroRNAs; PDAC; Targets; Prognostic and predictive biomarker

Cite the Article:

Ghasemi F, Shahid Sales S, Hassanian SM, Avan A. Prognostic and Predictive Values of MicroRNAs in Pancreatic Cancer. Clin Oncol. 2016; 1: 1077.