Prognostic Significance of Inflammatory Cytokines in Obese Patients with Endometrial Cancer Undergoing Robotic Versus Laparotomy Procedures

Dimitrov T, Gorchev G, Tomov S, Sarfraz A, Kameliya, Tsvetanova, Tantchev L, Malkodanski I and Ivanova I

Department of Gynecological Oncology, Medical University of Pleven, Bulgaria
Department of Gynecologic Oncology, Florida Hospital Cancer Institute, USA

^*Correspondance to: Todor Dimitrov 

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Abstract:

Several biological mechanisms mediate the association between obesity and endometrial neoplastic risk. The increased body mass index (BMI) with >30 kg/m2 is also associated with the long-term maintaining of a high level of inflammatory processes, increased pro-inflammatory cytokines, and acute-phase inflammatory proteins. In the practice of gynecologic surgeons, there is growing interest in monitoring a group of cytokines as independent prognostic factors (such as markers of aggressiveness and opportunity for better therapeutic influence on the neoplastic process). We report on the monitoring of cytokine profiles of interleukin (IL)-8, tumor necrosis factor (TNF)-α and their association with C-reactive protein (CRP) in the serum of patients with stage I endometrial cancer treated with robotic-assisted laparoscopic hysterectomy (R) and traditional laparotomy/open (O) surgical procedures. The patients’ age ranged from 46-81 years. Compared to the pre-surgical specimens, the levels of IL-8, TNF-α and CRP were substantially higher in post-surgical specimens, particularly at 3rd hour. Regardless of the pre- or post-surgical time points, the levels of these cytokines/mediators have been significantly higher in morbidly obese patients with BMI >40 kg/m2. It is conclude that the inflammatory cytokines and acute phase proteins contribute to the prognostic assessment in the neoplastic disease, particularly in morbidly obese endometrial cancer patients. Immune-sparing role of robotic-assisted surgery as compared to open surgery seems to be a better treatment option for overweight women with early-stage endometrial cancer.

Keywords:

Endometrial cancer; Obesity; Inflammatory cytokines; Robotic surgery; Prognosis

Cite the Article:

Dimitrov T, Gorchev G, Tomov S, Sarfraz A, Kameliya, Tsvetanova, et al. Prognostic Significance of Inflammatory Cytokines in Obese Patients with Endometrial Cancer Undergoing Robotic Versus Laparotomy Procedures. Clin Oncol. 2016; 1: 1076.