Clinical Manifestations of Late Isolated Metachronous Brain Metastases after Colorectal Cancer Hepatic Metastectomy

Lakoma A and Curley SA

Department of Surgery, Section of Surgical Oncology, Baylor College of Medicine, USA

^*Correspondance to: Steven A. Curley 

 PDF  Full Text Research Article | Open Access

Abstract:

Isolated brain metastases in patients in remission after successful colorectal cancer hepatic metastectomy are rare and not well characterized. Generally, the central nervous system is an uncommon site for metastasis in patients with stage IV colorectal cancer. Herein, we present a case series of patients diagnosed with isolated, metachronous brain metastases that arose in patients who had been disease-free for more than five years after resection of liver metastases. The incidence of this metastatic pattern is very low and the time to presentation is late, being an average of almost 10 years after hepatic metastectomy. Notably, all nine patients presented with onset of new neurologic symptoms leading to axial brain imaging studies which demonstrated metastatic disease. Hence, new neurologic symptoms in long-term stage IV colorectal cancer survivors warrants immediate notification of treating physicians for evaluation, as late metachronous brain metastasis is a potential diagnosis.

Keywords:

Colorectal cancer; Stage IV; Liver metastases; Brain metastases

Cite the Article:

Lakoma A, Curley SA. Clinical Manifestations of Late Isolated Metachronous Brain Metastases after Colorectal Cancer Hepatic Metastectomy. Clin Oncol. 2016; 1: 1071.