The Effect of Myometrial Invasion Pattern to Stage in Endometrial Cancer

Uslu E, Yalcin OT, Kabukcuoglu S, Ozalp SS and Oge T

Department of Obstetrics and Gynecology, Eskisehir Osmangazi University School of Medicine, Turkey
Department of Pathology, Eskisehir Osmangazi University School of Medicine, Turkey

^*Correspondance to: Kabukcuoglu S 

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Abstract:

Aim: Myometrial invasion (MI) is one of the prognostic factors in endometrial cancer (EC). It has been argued that myometrial invasion pattern (MIP) is associated with prognosis. Our aim is to evaluate MIP in patients with EC.
Materials and Methods: The patient who had total abdominal hysterectomy, bilateral salpingooophorectomy, in fracolicomentectomy, pelvic-paraaortic lymphadenectomy, cytological sampling and also has a result of EC in postoperative pathology between May 2014- October 2015 in our clinic were included. Specimens were hystopathological classified as properly limited (pushing, PL), diffusely infiltrative (DI), adenomyozisinvolment by EC (A), microcystic, elongated and fragmented (MELF) groups by the same pathologist. The relationship between the MIP and stage and grade of endometrial cancer were evaluated.
Results: One hundred patients was operated and mean age was 57.4 ± 9.32 years. PL, DI, A, MELF patterns were observed in 41,14,17,28 patients respectively. Distribution of myometrial invasion patterns to stages, MELF pattern was observed mostly in Stage 3(n=12, 42.9%). Properly limited (n=30, 73.2%,), DI(n=5, 35.7%) and AL(n=9 , 52.9%) patterns are observed mostly in Stage 1A(P=0,001). Moreover, grade 1 was observed in most of the PL (n=6, 75%), andgrade 3 was observed in most MELF pattern in endometrial cancer (n=10, 52.6%)(P=<0,001). Conclusions: MELF pattern was mostly observed in patients with high grades and stages of endometrial cancer. Properly limited pattern was mainly observed in low grade and stage of endometrial cancer. Further studies are needed to evaluate the clinical significance of this observation

Keywords:

Endometrial cancer; Myometrial invasion pattern; Stage; Immunohistochemistry

Cite the Article:

Uslu E, Yalcin OT, Kabukcuoglu S, Ozalp SS, Oge T. The Effect of Myometrial Invasion Pattern to Stage in Endometrial Cancer. Clin Oncol. 2016; 1: 1048.