Managing Extremity Soft Tissue Sarcomas Before Definitive Surgery; Preoperative Radiotherapy Alone or Combined Modality Strategies?

Rick LM Haas

Department of Radiotherapy, The Netherlands Cancer Institute Amsterdam, Netherlands

^*Correspondance to: Rick L.M 

 PDF  Full Text Review Article | Open Access

Abstract:

Introduction: This critical review aims to summarize published data on pre-operative radiotherapy (RT) with or without concurrent systemic therapy followed by limb sparing surgery for extremity soft tissue sarcoma.
Methods: This review is based on peer-reviewed publications using a PubMed search on the MeSH headings “soft tissue sarcoma” AND “preoperative radiotherapy” AND “chemotherapy” AND/ OR “targeted agents AND/OR tyrosine kinase inhibitors”, are collated. Reference lists from some articles have been studied to obtain other pertinent articles. Additional information on relevant clinical trials available at the ClinicalTrials.gov website was also added.
Results: Data are presented for the conventional regimen of 50-50.4 Gy in 25-28 fractions in 5-6 weeks preoperative external beam RT alone or in combination with conventional chemotherapy and/or targeted agents.
Conclusion: Outside the setting of well-designed prospective clinical trials, the conventional 50 Gy in 5-6 weeks schedule should be considered as standard. However, current and future studies addressing combinations with chemotherapy and/or targeted agents may reveal regimens of equal or increased efficacy with reduced late morbidities.

Keywords:

Limb soft tissue sarcoma; Surgery; Preoperative radiotherapy; Combined modality treatment; Targeted agents; Chemotherapy

Cite the Article:

Rick LM Haas. Managing Extremity Soft Tissue Sarcomas Before Definitive Surgery; Preoperative Radiotherapy Alone or Combined Modality Strategies? Clin Oncol. 2016; 1: 1047.