Aggressive T-cell Large Granular Lymphocytic Leukemia Presenting as an EBV Negative Post-Transplant Lymphoproliferative Disorder

Leeborg N, Loriaux M and Huang JZ

Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR, USA
A 33 year-old man, a renal transplant recipient, developed an aggressive T-cell large granular lymphocytic leukemia (LGL) that presented as a soft-tissue lesion, mimicking an abscess. The tumor cells showed cytological features of large granular lymphocytes, immunophenotypically characterized as mature T-cells expressing CD2, CD5, CD4, CD56, and TIA-1. About 80% of tumor cells were positive for Ki-67 and p53. Cytogenetic analysis demonstrated trisomy 8, trisomy 15, and trisomy 21. There was no evidence of Epstein-Barr virus infection. The patient died 14 days after diagnosis with multiple organ failure and extensive bone marrow and visceral involvement. Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, MI, USA and Department of Pathology and Laboratory Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA

^*Correspondance to: James Z Huang 

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Abstract:

A 33 year-old man, a renal transplant recipient, developed an aggressive T-cell large granular lymphocytic leukemia (LGL) that presented as a soft-tissue lesion, mimicking an abscess. The tumor cells showed cytological features of large granular lymphocytes, immunophenotypically characterized as mature T-cells expressing CD2, CD5, CD4, CD56, and TIA-1. About 80% of tumor cells were positive for Ki-67 and p53. Cytogenetic analysis demonstrated trisomy 8, trisomy 15, and trisomy 21. There was no evidence of Epstein-Barr virus infection. The patient died 14 days after diagnosis with multiple organ failure and extensive bone marrow and visceral involvement.

Keywords:

T-cell large granular lymphocytic leukemia; Post-transplant lymphoproliferative disorder

Cite the Article:

Leeborg N, Loriaux M, Huang JZ. Aggressive T-cell Large Granular Lymphocytic Leukemia Presenting as an EBV Negative Post-Transplant Lymphoproliferative Disorder. Clin Oncol. 2016; 1: 1007.