Editorial
Rapid Spontaneous Regression of Diffuse Large B-Cell Lymphoma after Fine Needle Aspiration Cytology: A Case Report
Adel El-Badrawy1*, Reham Abd El-Wahab1, Ziad Emarah2 and Noha Eisa3
1Department of Radiology, Mansoura University, Egypt
2Department of Medical Oncology, Oncology Center- Mansoura University, Egypt
3Department of Clinical Hematology, Mansoura University, Egypt
*Corresponding author: Adel El-Badrawy, Department of Radiology, Mansoura University, 1 Omar Ben Abdel-Aziz From Gehan Street – Mansoura, Egypt
Published: 11 May, 2018
Cite this article as: El-Badrawy A, Abd El-Wahab R,
Emarah Z, Eisa N. Rapid Spontaneous
Regression of Diffuse Large B-Cell
Lymphoma after Fine Needle Aspiration
Cytology: A Case Report. Clin Oncol.
2018; 3: 1455.
Editorial
Spontaneous Regression (SR) of lymphoma is a rare phenomenon. While the precise mechanism
of SR remains unknown, apoptosis may be associated with its process. Here, we present a case of
a 45-year-old woman was admitted to our hospital with jaundice. Ultrasonography revealed porta
hepatis mass with dilated intra-hepatic bile ducts. Patient underwent percutaneous transhepatic
biliary drainage. Multi-detector computed tomography of showed porta hepatis mass compressing
extra-hepatic duct with dilated intra-hepatic bile ducts as well as splenic focal lesion (Figure 1).
Fine Needle Aspiration Cytology (FNAC) was done and revealed lymphocytic smear with advised
another biopsy. US guided FNAC was taken after 17 days. During US guided technique; marked
regression of porta hepatis mass was detected. So, 2nd biopsy was taken from splenic focal lesion.
Post-contrast MDCT scan was done and revealed marked decrease in size of porta hepatis mass after
18 days (Figure 2). Final pathology revealed non-Hodgkin lymphoma (diffuse large B-cell type).
The mechanism of spontaneous regression of malignant tumor is unknown, however, several
of these regressions occurred after invasive procedures such as biopsies, or after complications with
bacterial infection; some may have activated immune reactions, which might have contributed to
the resolution of the disease [1].
Abe et al. [2] reviewed 15 cases of Spontaneous Regression (SR) in Non-Hodgkin Lymphoma
(NHL) and reported that 3 cases involved were Diffuse Large B Cell
Lymphoma (DLBCL) type. Most of SR cases are localized tumors
stage I or IE that has undergone invasive procedure like excision
biopsy and have been associated with a massive infiltration of T cells
in the residual tissue. Spontaneous regression of pulmonary Mucosa-
Associated Lymphoid Tissue (MALT) lymphoma was found after
open lung biopsy [3]. Another spontaneous regression of orbital
Non-Hodgkin lymphoma, diffuse large B cell type was shown after
biopsy [4].
In the present case, there was rapid diffuse large B-cell lymphoma
regression following fine needle aspiration cytology. Stimulation by
fine needle biopsy may have directly triggered a regional immune
reaction, which could have led to tumor remission. It has been
hypothesized that FNAC may initiate immunologic mechanisms
that may be involved in the regression. Immunological evaluation of
patient with diffuse large B-cell lymphoma must be assessed before
and after biopsy to detected immune-directed therapies. More reports
of such cases should help to clarify the mechanisms, contribute to a
further understanding of this phenomenon and may lead to a new
treatment strategy for diffuse large B-cell lymphoma.
Figure 1
Figure 1
Initial post-contrast MDCT scan of the abdomen (A-C) done on August 20, 2017 reveal porta hepatis
mass with intra-hepatic bile duct dilatation. Hyper dense shadow in image C revealed inner tip of bile drainage
catheter. Evidence of splenic focal lesion.
Figure 2
Figure 2
Post-contrast MDCT scan done on September 7, 2017 (after 18 days) reveal marked regression of the
porta hepatis mass with no change as regard splenic focal lesion.
References
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- Abe R, Ogawa K, Maruyama Y, Nakamura N, Abe M. Spontaneous regression of diffuse large B-cell lymphoma harbouring Epstein-Barr virus: A case report and review of the literature. J Clin Exp Hematop. 2007;47(1):23-6.
- Hye Seon Kang, Hea Yon Lee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Gyeong Sin Park, et al. Case report: An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression. Cancer Res Treat. 2015;47(4):943-8.
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