Research Article

Neoadjuvant Immunotherapy in High Risk Patients with Cutaneous Melanoma: A Novel Approach

Cutaneous melanoma is an immunogenic tumor, but it seems to be very heterogeneous. Utilizing patient own tumor, before it excision, as the source for tumor-specific antigens, intratumoral administration of low dose of GM-CSF weekly in dermal and subdermal metastases did result in over 50% response rate.

Published 27 Aug, 2016


Research Article

The Impact of a Dedicated Palliative Care Unit on a Busy Medical Intensive Care Unit in an Academic Setting; a Retrospective Review

Introduction: Palliative care aims to maximize quality of life for those patients facing serious illness. There is growing evidence to demonstrate that palliative care (PC) consultation teams have been associated with improvement in quality markers such as reduction in intensive care unit length of stay (LOS) and mortality

Published 26 Aug, 2016


Short Communication

Malignant Potential of Seemingly Naive Chronic Arsenicosis

World Health Organization working group defines Arsenicosis as a "chronic health condition arising from prolonged ingestion (not less than 6 months) of arsenic above a safe dose, usually manifested by characteristic skin lesions with or without involvement of internal organs".

Published 26 Aug, 2016


Research Article

Can High-Grade Prostate Cancer (Gleason 8-10) be Cured with Definitive Local Therapy without Hormone Suppression? Disease Control and Survival Outcomes after Up-Front Radical Prostatectomy in Patients with High-Grade Clinically Localized Disease

Background: High-grade prostate cancer (HGPC) is associated with an aggressive clinical course and poor outcomes, thus testosterone-suppressive hormone therapy (HT) frequently accompanies definitive local therapy.

Published 25 Aug, 2016


Case Report

A Case Report of Non-Secretorymyeloma with Renal Failure

Non-secretory myeloma (NSM) is a rare form of multiple myeloma with the feature of absence of monoclonal gammopathy in serum and urine by immunofixation electrophoresis.

Published 02 Jul, 2016


Case Report

Targeting RAGE Expression in Human Ovarian Cancer

Receptor for Advanced Glycation Endproducts (RAGE) is expressed in ovarian tissue and associated with ovarian carcinoma.

Published 30 Jul, 2016


Research Article

Distinguishing Malignant from Benign Prostate Tumors using Br, Fe, Rb, Sr, and Zn Content in Prostatic Tissue

Contents of Br, Fe, Rb, Sr, and Zn in normal (n=37), benign hypertrophic (n=43) and cancerous tissues (n=60) of the human prostate gland were investigated by radionuclide-induced (109Cd) energy dispersive X-ray fluorescent (EDXRF).

Published 13 Jul, 2016


Commentary

Birth Order in Malignant Hematological Disorders: A Challenge

A birth order effect (BOE) is a non-random occurrence of affected siblings in a sib ship. Thus, in case of BOE the affected child has a specific and significant birth rank order by age, for example first child, early in the sib ship, in the middle or late [1].

Published 01 Jul, 2016


Review Article

Haploidentical Hematopoietic Stem Cell Transplantation for Acute Leukemia: Early Hype or Sustained Enthusiasm

Allogeneic hematopoietic stem cell transplantation (HSCT) is probably the only curative option for the majority of patients suffering from acute leukemia, either in first complete remission or after relapse [1-3].

Published 15 Jul, 2016


Review Article

Factors Predictive of Survival in Synovial Sarcoma; a Review of the Literature

Background: Synovial sarcomas are a rare malignant mesenchymal soft tissue tumour, with generally poor prognosis due to a high degree of local invasiveness and propensity to metastasise.

Published 29 Jul, 2016


Case Report

A Case of High Grade Advanced Neuroendocrine Cancer of the Bladder Treated with Bevacizumab, Cisplatin, Etoposide and Cyclophosphamide-Based Chemotherapy

Neuroendocrine bladder cancer accounts for <1% of all bladder cancers. There is no standard treatment for neuroendocrine bladder cancer; instead therapy is mainly based on agents used in small cell lung cancer.

Published 10 Jun, 2016


Case Report

Uterine Carcinosarcoma after Pelvic Radiotherapy

Radiation is a treatment of many gynecologic malignancies, especially locally-advanced cervical cancer. Development of second malignancies is a rare complication of radiotherapy.

Published 15 Jul, 2016


Research Article

The Effect of Myometrial Invasion Pattern to Stage in Endometrial Cancer

Aim: Myometrial invasion (MI) is one of the prognostic factors in endometrial cancer (EC). It has been argued that myometrial invasion pattern (MIP) is associated with prognosis.

Published 29 Jul, 2016


Review Article

Managing Extremity Soft Tissue Sarcomas Before Definitive Surgery; Preoperative Radiotherapy Alone or Combined Modality Strategies?

Introduction: This critical review aims to summarize published data on pre-operative radiotherapy (RT) with or without concurrent systemic therapy followed by limb sparing surgery for extremity soft tissue sarcoma.

Published 02 Jul, 2016


Research Article

Robotic Radical Prostatectomy and Urinary Continence: Posterior Reconstruction is Better

Robotic radical prostatectomy (RARP) is the gold standard for localised prostate cancer. However, a younger cohort are presenting with more locally advanced disease.

Published 02 Jul, 2016


Review Article

Muscle Invasive Bladder Cancer: To Cystectomise or Not? The Role of Neoadjuvant Chemotherapy

Background: Bladder cancer is one of the most common cancers in the western world with associated significant mortality.

Published 15 Jul, 2016


Review Article

Cyclin D1 Expression in Triple-Negative Breast Cancer with New Treatment Implications

While targeted therapies are available for breast cancer patients whose tumors express ER, PR, or show HER-2 overexpression, no such treatment exists for "triple-negative" cases.

Published 29 Jul, 2016


Research Article

Robotic Radical Prostatectomy-Continence and Oncological Outcomes in 707 Cases

Introduction: Robotic laparoscopic assisted radical prostatectomy is now considered the gold standard for localized prostate cancer.

Published 20 Jul, 2016


Review Article

Late Cardiac Effects of Therapy for Hodgkin Lymphoma

Hodgkin lymphoma (HL) is a leading cause of cancer among adolescents, and is often cured with chemotherapy alone or in combination with radiation therapy.

Published 15 Jul, 2016


Case Report

Tubo-Ovarian Abscess Misdiagnosed Ovarian Malignancy

Tubo-ovarian abscess (TOA) is a severe sequele of pelvic inflammatory disease. The diagnosis is dependent on the aspects of medical history, physical examination, laboratory tests and imaging.

Published 15 Jul, 2016





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