Hua Pan1, Shihong Shao2, Maoqing Xing3, Aiqin Song1, Enben Guan1, Liang Song1, Xiaodan Liu1 and Yanxia Zhao4*
1Department of Pediatric Intensive Care Unit, Affiliated Hospital of Qingdao University, China
2Department of Pathology, Affiliated Hospital of Qingdao University, China
3Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, China
4Department of Hematology of Pediatrics, Affiliated Hospital of Qingdao University, China
Epstein-Barr virus (EBV) positive Mucocutaneous Ulcers (EBVMCU) represent a newly recognized although uncommon disease, especially in children. Here we report an extremely rare case of a 17-month-old girl with intestinally localized EBVMCU EBV-associated hemophagocytic lymphohistiocytosis causing gastrointestinal bleeding without genetic abnormalities. Amongst
a range of tests used, pathological examination and immunochemistry proved mandatory for diagnosis. Thus, although rare, it is essential that physicians must be aware of this new disease for both accurate diagnosis and treatment.
EBV-positive mucocutaneous ulcer; Gastrointestinal bleeding; EBV-associated hemophagocytic lymphohistiocytosis
Pan H, Shao S, Xing M, Song A, Guan E, Song L, et al. The Etiology of Gastrointestinal Bleeding with EBV - Associated Hemophagocytic Lymphohistiocytosis in Intestinal EBV-Positive Mucocutaneous Ulcer: A Rare Pathological Entity. Clin Oncol. 2022;7:1947..