Andrea Z Pereira1*, Bianca de Almeida-Pitito2, Rogério Ruscitto do Prado1, Andre Mattar3, Roberto Hegg3, Jorge Yoshinori Shida3 and Luiz Henrique Gebrim3
1Department of Oncology and Hematology, Albert Einstein Hospital, Brazil
2Department of Preventive Medicine, UNIFESP, Brazil
3Department of Breast Cancer, São Paulo State Government Women's Health Reference Center (Pérola Byington Hospital), Brazil
Background: There is a higher risk of Breast Cancer (BC) in postmenopausal obese women and with a worse outcome of all ages.
Objectives: To evaluate obesity prevalence in BC patients and its association with survival, age, Surgery Complications (SC), and molecular BC subtypes.
Methods: A retrospective cohort study was performed with 5925 between 1994 and 2018. Survival analysis was performed according to Body Mass Index (BMI) groups. The database contains information about molecular BC subtypes and SC.
Results: They had a mean (SD) age of 54 (12.0) years. There were 769 (13%) deaths, and the mean survival was 20 (2.0) years. 1,787 (30%) patients with obesity and 4,138 (70%) without obesity. Patients with obesity were older (56 (11.0) years) (p<0.001) and they had lower frequencies of luminal B (33 vs. 67%, p=0.02) and HER2- (31 vs. 69%, p=0.04) subtypes. There was a difference between obesity in BC patients and the Brazilian population (p<0.005). Patients with obesity had more infections as a SC (p=0.01). The Kaplan-Meier curve shows the estimates of survival for patients with obesity and patients without obesity with BC.
Conclusion: We found a high prevalence of obesity in BC patients, more than in the general Brazilian women population. Our patients with obesity were older and had lower frequencies of luminal B and HER2-subtypes than women without obesity. Besides that, patients with obesity had more infections after surgery, mainly in HER2+, Negative triple, and HER2+ Hybrid.
Breast cancer; BMI; Obesity; Follow-up-infection
Pereira AZ, de Almeida-Pitito B, do Prado RR, Mattar A, Hegg R, Yoshinori Shida J, et al. Overview of Obesity and Breast Cancer in Brazil: 24 Years of Follow-Up. Clin Oncol. 2021;6:1836..