Wang P, He Y, Wang J, Ye Q, Zhang H* and Zhang W*
Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, ChinaFulltext PDF
TCF3-HLF-fusion positive Acute Lymphoblastic Leukemia (ALL) is very rare and nearly incurable according to current standard chemotherapy even with hematopoietic stem cell transplantation. Optimized treatment strategies are urgently needed. In this report we present two cases with TCF3-HLF fusion with different therapeutic regimens and review ever reported cases in literature. We proposed that combination of BCL2 antagonist venetoclax with non-aggressive chemotherapy should be considered for this fatal subtype ALL in the future.
TCF3-HLF; Acute lymphoblastic leukemia; BCL2 antagonist venetoclax; Nonaggressive chemotherapy
Wang P, He Y, Wang J, Ye Q, Zhang H, Zhang W. BCL2 Antagonist Venetoclax Combined with Non-Aggressive Chemotherapy in Treating Fatal TCF3-HLF Positive Acute Lymphoblastic Leukemia. Clin Oncol. 2021;6:1830..