Clin Oncol | Volume 6, Issue 1 | Research Article | Open Access

Effects of Exercise on Physical Function and Quality of Life in Prostate Cancer Patients Receiving Androgen Deprivation Therapy: High Intensity Interval Training vs. Moderate-Intensity Continuous Training

Sangjun Yoo1, Kyung Hee Lee2, Parivash Jamarasi2, Min Chul Cho1, Wook Song2,3* and Hyeon Jeong1*

1Department of Urology, Seoul National University, Boramae Medical Center, Korea
2Institute of Sport Science, Seoul National University, Korea
3Institute on Aging, Seoul National University, Korea

*Correspondance to: Hyeon Jeong 

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Purpose: We assessed the effects of exercise on the physical function and health Quality of Life (hQoL) in prostate cancer patients underwent Androgen Deprivation Therapy (ADT). Additionally, the effects of High-Intensity Interval Training (HIIT) were compared with Moderate-Intensity Continuous Training (MICT).
Methods: Seventeen prostate cancer patients underwent ADT were prospectively allocated to either HIIT or MICT. Physical function and hQoL were measured before and after 12-week and 3 to 6 months after the exercise, respectively.
Results: Although the whole-body total mass significantly increased after the exercise, it was equivalent regardless of the methods. After the exercise, muscle strength and endurance improved and tended to be maintained until 3 to 6 months later. Improvement in muscle endurance was more prominent after HIIT, and that in muscle strength was more prominent after MICT. Performance in the senior fitness test improved after the exercise, and HIIT was more effective for lower and upper muscle endurance and flexibility although MICT was more effective for the others. hQoL significantly improved at 3 to 6 months after the exercise.
Conclusion: 12-week exercise has a positive effect on the physical function and hQoL in prostate cancer patients underwent ADT. In these patients, HIIT may be a better option for improving muscle endurance, to prevent falls and fracture.


High-intensity interval training; Prostate cancer; Androgen deprivation therapy; Body composition; Muscle function


Yoo S, Lee KH, Jamarasi P, Cho MC, Song W, Jeong H. Effects of Exercise on Physical Function and Quality of Life in Prostate Cancer Patients Receiving Androgen Deprivation Therapy: High Intensity Interval Training vs. Moderate-Intensity Continuous Training. Clin Oncol. 2021;6:1812..

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