Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Hormone Therapy
- Colon Cancer
- Lymphoma
- Central Nervous System Tumors
- Haemato-Oncology
- Chemoprevention
- Hematology
- Breast Cancer
Abstract
Citation: Clin Oncol. 2021;6(1):1791.DOI: 10.25107/2474-1663.1791
Lymphoma Diagnosis: Lessons Learned from the Comparison of Histology and Cytology Associated with Flow Cytometry
Guillaume Aussedat, Juliette Fontaine, Luc-Marie Gerland, Alexandra Traverse-Glehen and Lucile Baseggio
Department of Clinical Hematology, Lyon-Sud Hospital Group/Hospices Civils de Lyon, France
Department of Anatomy-Pathology, Lyon-Sud Hospital Group/Hospices Civils de Lyon, France
Specialized Hematology Laboratory, Lyon-Sud Hospital Group/Hospices Civils de Lyon, France
*Correspondance to: Lucile Baseggio
PDF Full Text Case Series | Open Access
Abstract:
For lymphoma diagnosis, the Flow Cytometry (FCM) and cytology associated with FCM (C-FCM) performed on Fine Needle Aspiration (FNA) or cell suspension/imprints from fresh tissue display a good concordance (from 85% to 90%) with the diagnosis made using histological data. Herein is reported a retrospective series of discordant cases, five of them are discussed in details, and some recommendations are proposed for the interpretation of C-FCM data. Firstly, this review highlights the importance of analyzing simultaneously the cytological and FCM data. In particular, the cytological data are crucial to interpret FCM data and/or to complete Ab panels when the strategy of the laboratory is to systematically perform a first screening, which does not always allow detecting lymphoma cells. Secondly, this report underlines that cytology and FCM analysis should be followed by a confrontation/discussion with a pathologist. Finally, C-FCM appears to be a rapid and particularly important technique to guide the choice of the following diagnosis tools (IHC and genetic).
Keywords:
Cytology; Flow cytometry; Lymphoma; Histology
Cite the Article:
Aussedat G, Fontaine J, Gerland L-M, Traverse-Glehen A, Baseggio L. Lymphoma Diagnosis: Lessons Learned from the Comparison of Histology and Cytology Associated with Flow Cytometry. Clin Oncol. 2021;6:1791..