SARS-CoV-2 Infection in an Adolescent after Haploidentical Stem Cell Transplantation

Massei MS, Capolsini I, Cerri C, Gurdo G, Mastrodicasa E, Perruccio K, Brogna M, Gorello P, Ruggeri L, Rosignoli D, Marchesi M, Luciani Pasqua B, Mencacci A, Caniglia M and Arcioni F

Department of Pediatric Oncology-Hematology, Santa Maria della Misericordia Hospital, Italy
Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Italy
Department of Medicine, University of Perugia, Italy
Deaprtment of Immunohematology, Santa Maria della Misericordia Hospital, Italy

^*Correspondance to: Francesco Arcioni 

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Abstract:

COVID-19 infection currently represents the global health emergency that all health professionals must face. In particular, many aspects remain to be clarified regarding morbidity and causes of mortality in the general population. Even more are the aspects to be clarified regarding the characteristics of this infection in the immunocompromised population. In particular, in patients undergoing bone marrow transplantation there are only sporadic observations about the course of the disease, this also because the transplanted patient observes the rules of social distancing unrelated to the pandemic, resulting consequently involved in rare cases by the infection. However, the degree of lethality of COVID-19 infection, in the rare observations available up to now, appears to be lower in the immunocompromised patient. In April 2020 the European Society for Blood and Marrow Transplantation (EBMT) therefore developed recommendations for transplant programs and physicians treating HSCT patients. We describe the case of a haploidentical bone marrow transplantated patient who contracted COVID-19 infection at day +110 from transplantation
during immunosuppressive treatment for the presence of GvHD. The study and observation of these rare cases could help hematologists and transplantologists to better manage the infections that will continue to present themselves given the pandemic course, and could also help to better understand the mechanisms of morbidity of the virus to search for some physiopathological and therapeutic aspects that can be transferred to the general population.

Keywords:

Stem cell transplantation; SARS-CoV-2 infection; Acute leukemia

Cite the Article:

Massei MS, Capolsini I, Cerri C, Gurdo G, Mastrodicasa E, Perruccio K, et al. SARS-CoV-2 Infection in an Adolescent after Haploidentical Stem Cell Transplantation. Clin Oncol. 2021;6:1787..