Lawrence M Agius*
Department of Pathology, Mater Dei Hospital, MaltaFulltext PDF
The basis of biology of immunodominance of antigens is defining term in the evolution of a specific antigenicity as carried forward by complex dimensions of an immune response to tumor epitopes. In such terms, immune pressure dynamics contextualize the evolving process of epitope redistribution as anergic states of non-reactivity or as terms of reference in defining such immunodominance of given antigenicity of individual tumor cells. It is further to such considerations that quantitative antigen presentation both correlates with evolution of antigen binding to the Major Histocompatibility Complex (MHC) structured molecules and with system profiles of redistribution inherent to antigen presentation on the surface membrane of both antigen presenting cells and also tumor cells.
Agius LM. Immunodominance as Complex Patterned Interplay of Antigen Quantitation Phenomena in Pressure Immunity. Clin Oncol. 2020; 5:1762..