Clin Oncol | Volume 5, Issue 1 | Case Report | Open Access

The Diagnosis Challenge of Cutaneous Localization of Hepatosplenic T-Cell Lymphoma

Lamia Charfi1, Yosra Yahyaoui2*, Yoldez Houcine1, Ghada Sahraoui1, Rym Sellami Dhouib1, Karima Mrad1 and Raoudha Doghri1

1Department of Pathology, Salah Azaïz Institute, Tunisia 2Department of Oncology, Salah Azaïz Institute, Tunisia

*Correspondance to: Yosra Yahyaoui 

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Hepatosplenic T-cell Lymphoma (HSTL) is characterized by predominant involvement of liver, spleen and bone marrow, and an often aggressive course. Lymphadenopathy is rarely observed and involvement of skin is exceptional making recognition of cutaneous localization a diagnostic challenge. We report a case of 30-year-old woman presented with generalized pruritic and erythematous plaques, irregular fever, and obvious abdominal distension. The patient was treated for psoriasis for the past 7 years, by various doctors in tertiary centers, with topical steroid and methotrexate without much control. The patient's condition further worsened, and she developed multiple new plaques in the past 8 months. Investigations revealed thrombocytopenia with hepatosplenomegaly. Skin biopsy showed atypical lymphoid cells involving the dermis with expression of CD3, CD7, CD56 and cytotoxic granule-associated proteins (TIA1, Granzyme B and Perforin), and were negative for CD20, CD2, CD4, CD5, CD8, CD30, ALK and TdT (Terminal deoxynucleotidyl Transferase). The diagnosis of a skin localization of a HSTL was performed. The patient was treated with chemotherapy.


Hepatosplenic T-cell lymphoma; Cutaneous lymphoma; Skin


Charfi L, Yahyaoui Y, Houcine Y, Sahraoui G, Sellami Dhouib R, Mrad K, et al. The Diagnosis Challenge of Cutaneous Localization of Hepatosplenic T-Cell Lymphoma. Clin Oncol. 2020; 5: 1742.

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