João Vasco Barreira1*, Gil Falcão2, Anuraj Parmanande1 and Luís Campos Pinheiro2
1Department of Oncology, Hospital Center of Central Lisbon, Portugal 2Department of Urology, Hospital Center of Central Lisbon, PortugalFulltext PDF
Carcinoma of the bladder is the second most common genitourinary malignancy and is associated with a heterogeneous clinical outcome. Prognostic assessment is essential for treatment decisionmaking, patient counseling, and determination of eligibility for clinical trials and could help in individualized treatment and follow up. A retrospective analysis of a single university hospital was performed, through the electronic process of all patients undergoing radical cystectomy between January 2014 and January 2019 (5 years), to evaluate the influence of clinical and histopathological parameters on outcomes of patients with carcinoma of the bladder. Eighty-three (83) patients were analyzed. The following factors were evaluated: age, gender, smoking habits, comorbidities (Charlson Index), tumor stage, tumor differentiation, histological variant, necrosis, Lymphovascular/Perineural Invasion (LVI/PNI), concomitant Carcinoma In Situ (CIS), presence of lymph node metastasis, disease recurrence and performance of neoadjuvant chemotherapy. Of all the factors evaluated, a statistically significant relationship was observed between Overall Survival (OS) and tumor stage, presence of lymph node metastasis and disease recurrence. The small sample size may justify the non-association of other factors as predictive of survival. Prospective trials for better selection of patients are warranted.
Barreira JV, Falcão G, Parmanande A, Pinheiro LC. Evaluation of Prognostic Factors for Survival in Bladder Cancer. Clin Oncol. 2020; 5: 1725.