Survival after Parotid Gland Metastases of Cutaneous Squamous Cell Carcinoma of the Head and Neck

Meyer MF, Wolber P, Arolt C, Wessel M, Quaas A, Lang S, Klussmann JP, Semrau Rand Beutner D

Department of Otorhinolaryngology, Head and Neck Surgery, University Duisburg-Essen, Germany Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Germany Department of Pathology, University Hospital of Cologne, Germany Radiotherapy Bonn-Rhein-Sieg, Germany Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Germany

^*Correspondance to: Moritz Meyer 

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Abstract:

Introduction: Malignant tumors in the parotid gland can originate either from the gland itself or as a result of metastatic spread of other tumors, such as Cutaneous Squamous Cell Carcinomas (CSCC) of the head and neck area. The aim of this study was to analyze and compare the clinical behavior of primary as well as CSCC metastatic parotid cancers with special emphasis on therapy and oncologic outcome. Methods: Clinical and histopathological data of 342 patients with parotid gland malignoma surgically treated in a tertiary referral centre between 1987 and 2015 were retrospectively assessed. Oncologic outcomes of all cases with CSCC metastasis of the parotid gland (n=49) were compared to those of primary parotid gland carcinomas (n=293) Results: Mean age at diagnosis was 72.3 years for CSCC patients versus 56.8 years in patients with primary parotid carcinoma. 83.7% of CSCC patients were male, compared to 48.8% in the group of primary carcinomas. 45 out of 49 CSCC patients underwent total parotidectomy and neck dissection (91.8%). 93.9% out of all CSCC patients received adjuvant radiotherapy. Five year Overall Survival (OS) was 32.6% in CSCC patients versus 77.2% in primary parotid carcinoma patients. Conclusion: As compared to primary parotid cancers we could show that patients suffering from CSCC metastases to the parotid gland presented with significantly higher age and worse survival

Keywords:

Salivary gland carcinoma; Therapy; Survival; Cutaneous squamous cell carcinoma; Skin; Parotid

Cite the Article:

Meyer MF, Wolber P, Arolt C, Wessel M, Quaas A, Lang S, et al. Survival after Parotid Gland Metastases of Cutaneous Squamous Cell Carcinoma of the Head and Neck. Clin Oncol. 2020; 5: 1719.