Andrej D Kaprin1, Dmitrij S Merinov1, Dmitrij A Roshchin1, Aleksandr A Kachmazov1, Stanislav A Serebrianyi1, Dmitrij V Perepechin1, Shamil S Gurbanov1, Dmitry S Blinov2*, Pavel S Pilchuk3 and Ekaterina V Blinova4
1Department of Onco-Urology, National Medical Research Centre Radiology, The Ministry of Health of the Russian Federation, Russia
2Department of Research and Development, Care Mentor AI Russia,10, 2nd Tverskoy-Yamskoy Lane, Moscow, 125047, Russia
3Department of Urology, RUDN University, Russia
4Department of Operative Surgery and Clinical Anatomy, Sechenov University, Russia
Objectives: To implement novel approach to endoscopic organ-preserving surgery of patients with urothelial cancer of the upper urinary tract and access the outcomes of such treatment.
Methods: A seventy-two-year-old male and five females aged from 53 to 68 with T1 low grade urothelial carcinoma of the renal pelvis and/or ureter, with no need for hemodialysis, and life expectancy more than 5 years were assigned to endoscopic surgery. Transcutaneous or retrograde holmium laser-assisted removal of the renal pelvis tumor was applied as surgical techniques. Postoperative follow-up period was at least 3 months and included ureteroscopy or transcutaneous pyeloscopy to check urodynamic disturbances, absence of the tumor relapse and progression, possible complications and hemodialysis needs. Results: The operation time was 30 min to 80 min and depended on tumor localization. In all cases, blood loss did not go beyond 200 ml. Acute Pyelonephritis as a complication of early postoperative period developed in one patient after transcutaneous removal of pelvis tumor. Over the observation time (3 to 24 months) after surgery we registered no needs for hemodialysis; no signs of tumor recurrence were detected. Conclusion: Organ-preserving endoscopic treatment of patients with UTUC may be considered as promising and alternative for conservative tactics due to providing local control on the tumor progression.
Urothelial carcinoma; Organ-preserving surgery; Upper urinary tract; Renal pelvis; Ureter
Kaprin AD, Merinov DS, Roshchin DA, Kachmazov AA, Serebrianyi SA, Perepechin DV, et al. First Successful Experience of Organ-Preserving Endoscopic Surgical Treatment for Upper Urinary Tract Urothelial Carcinoma. Clin Oncol. 2020;5:1680.