Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Lung Cancers
  •  Palliative Care
  •  Urological Cancers
  •  Lymphoma
  •  Endometrial Cancer
  •  Leukemia
  •  Radiation Oncology
  •  Colon Cancer

Abstract

Citation: Clin Oncol. 2019;4(1):1675.DOI: 10.25107/2474-1663.1675

Brain Tissue Selectively Attacked by Adult T-Cell Leukemia/Lymphoma Cells: A Case Report

Tatsuro Jo, Masatoshi Matsuo, Jun Taguchi and Kazuto Shigematsu

Departments of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Japan Departments of Pathology, Japanese Red Cross Nagasaki Genbaku Hospital, Japan

*Correspondance to: Tatsuro Jo 

 PDF  Full Text Case Report | Open Access

Abstract:

We encountered an Adult T-cell Leukemia/Lymphoma (ATLL) patient with brain lesion without the involvement of any other organ. The patient exhibited amnesia, short-temper, and gait disturbance due to left hemiplegia. Brain Magnetic Resonance Imaging (MRI) revealed a broad edematous lesion in the right frontal lobe. Whole body examination by Computed Tomography (CT) demonstrated no other lesion except for the brain lesion. ATLL cells were not detected in peripheral blood. A tumor biopsy was conducted via craniotomy, and based on biopsy results; the patient was diagnosed with peripheral T-cell lymphoma positive for CD3 and negative for CD20 and EBV-encoded RNA. Human T-Lymphotropic Virus type 1 (HTLV-1) antibody was positive, and qualitative analysis of HTLV-1 proviral DNA, using DNA extracted from paraffin-embedded specimens, showed HTLV-1 positivity. Therefore, the patient was finally diagnosed with ATLL.

Keywords:

Adult T-cell leukemia/lymphoma; Brain invasion; DNA; CD3; CT

Cite the Article:

Jo T, Matsuo M, Taguchi J, Shigematsu K. Brain Tissue Selectively Attacked by Adult T-Cell Leukemia/Lymphoma Cells: A Case Report. Clin Oncol. 2019;4:1675.

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