Clin Oncol | Volume 4, Issue 1 | Case Report | Open Access

A Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of Literature

Amina Mokrani1, Fatma Guermazi1*, Asma Gargoura1, Wafa Koubaa2 , Yosra Yahyaoui1 , Feryel Letaief1 , Azza Gabsi1, Khedija Meddeb1 , Mouna Ayadi1 , Nesrine Chraiet1 , Henda Raies1 and Amel Mezlini1

1Department of Medical Oncology, Tunis El Manar University, Tunisia2Department of Pathology, Tunis El Manar University, Tunisia

*Correspondance to: Fatma Guermazi 

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Abstract

Pure Large Neuro Endocrine Carcinoma (LCNEC) of the gallbladder is so rare that until now only 10 cases have been described. Herein we aimed to report a new case treated in the Salah Azaiez National Cancer Institute in Tunisia. We also reviewed the clinical features of all cases reported so far. We reported the case of 67 years old men that had pure locally advanced LCNEC of the gallbladder, with posterior metastatic lymphadenopathy. He underwent a cholecystectomy followed by 6 cycles of Cisplatin and Etoposide chemotherapy, 3 cycles of gemcitabine and Capecitabine chemotherapy and a third line of metronomic Cyclophosphamide.

Keywords:

Gallbladder; Neuroendocrine carcinoma; Large cells; CRP; CT

Citation:

Mokrani A, Guermazi F, Gargoura A, Koubaa W, Yahyaoui Y, Letaief F, et al. A Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of Literature. Clin Oncol. 2019; 4: 1642 .

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