Scott M Eisenkop*
Gynecologic Oncology, Women’s Cancer Center, USAFulltext PDF
When feasible, advanced epithelial ovarian cancer is treated with primary cytoreductive surgery to resect all macroscopic disease followed by Platinum-based chemotherapy to achieve the best survival. It is suggested that chemotherapy be started as soon as possible following surgery, on the basis of theories as well as scientific and clinical evidence of residual microscopic disease progressing more rapidly after surgery than macroscopic disease and being more sensitive to chemotherapy. However, extensive clinical criteria are used to determine when do initiate chemotherapy and the clinical significance of a postoperative increase in the cancer cell kinetic growth rate and prognostic significance of the time to start chemotherapy for ovarian cancer is undetermined. Two cases are presented to address the issues of microscopic disease progression after surgery and additional issues in the investigation and management of ovarian cancer.
Ovarian cancer; Postoperative microscopic progression; Time to start chemotherapy; TTC
Eisenkop SM. Rapid Postoperative Growth of Ovarian Cancer- Two Case Reports. Clin Oncol. 2019; 4: 1570.