Moorthy Ganeshkumar1, Murthi Janani2, Thangavel Ponrasu1 and Lonchin Suguna1*
1Department of Biochemistry and Biotechnology, CSIR-Central Leather Research Institute, India
2Department of Biopharmaceutics, Anna University, India
In this study, microwave irradiated gold Nanoparticles were prepared using guar gum, a biopolymer, and utilized for targeted drug delivery for colon cancer for the first time. Guar gum stabilized gold Nanoparticles (GG-AuNPs) thus prepared, observed to possess hemocompatibility. 5-Fluorouracil (5-Fu), an anti-cancer drug, was adsorbed on GG-AuNPs ([email protected]) and used for targeted drug delivery for colon cancer. The toxicity and angiogenesis of 5-Fu, [email protected] was studied using zebrafish embryos. The cytotoxicity of free 5-Fu, [email protected] was carried out on HT-29 cells and found that the amount of 5-Fu required to achieve 50% of growth of inhibition (Ic50) was higher in [email protected] than in 5-Fu, due to a slow release of drug from Nanoparticles.
Gaur gum; Gold nanoparticles; Zebra fish; Colon cancer; Drug delivery
Ganeshkumar M, Janani M, Ponrasu T, Suguna L. Guar Gum Stabilized Gold Nanoparticles for Colon Cancer Treatment. Clin Oncol. 2018; 3: 1539.