Lu Qiao1,2, Ning Xie1,2, Yuru Bai1,2, Bin Qin1,2, Baicang Zou1,2, Yongquan Shi3, Yan Chen4, Jinhai Wang1,2* and Na Liu1,2*
1Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, China
2Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, China
3Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
4Department of Oncology, Xijing Hospital, the Fourth Military MedicalUniversity, Xi'an, China
Background: Gastric Cancer (GC) is one of the most common malignant tumors worldwide, while modest progress in diagnosis and treatment of gastric cancer have been made.Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern and prognostic value of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer.Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with including tumor invasion and TNM stage. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer.Conclusion: Our findings proved that NOX4 may be a prognostic factor or therapeutic marker for gastric cancer.
NOX4; Prognostic values; Gastric cancer
Qiao L, Xie N, Bai Y, Qin B, Zou B, Shi Y, et al. The Expression and Prognostic Value of NOX4 in Gastric Cancer. Clin Oncol. 2018; 3: 1505.