Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Targeted Therapy
  •  Brain and Spinal Cord Cancer
  •  Stomach Cancer
  •  Gynecological Cancers
  •  Immunotherapy
  •  Hematology
  •  Haemato-Oncology
  •  Hormone Therapy

Abstract

Citation: Clin Oncol. 2018;3(1):1505.DOI: 10.25107/2474-1663.1505

The Expression and Prognostic Value of NOX4 in Gastric Cancer

Lu Qiao, Ning Xie, Yuru Bai, Bin Qin, Baicang Zou, Yongquan Shi, Yan Chen, Jinhai Wang and Na Liu

Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, China
Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, China
Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Department of Oncology, Xijing Hospital, the Fourth Military MedicalUniversity, Xi'an, China

*Correspondance to: Jinhai Wang 

 PDF  Full Text Research Article | Open Access

Abstract:

Background: Gastric Cancer (GC) is one of the most common malignant tumors worldwide, while modest progress in diagnosis and treatment of gastric cancer have been made.Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern and prognostic value of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer.Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with including tumor invasion and TNM stage. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer.Conclusion: Our findings proved that NOX4 may be a prognostic factor or therapeutic marker for gastric cancer.

Keywords:

NOX4; Prognostic values; Gastric cancer

Cite the Article:

Qiao L, Xie N, Bai Y, Qin B, Zou B, Shi Y, et al. The Expression and Prognostic Value of NOX4 in Gastric Cancer. Clin Oncol. 2018; 3: 1505.

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