Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Targeted Therapy
- Brain and Spinal Cord Cancer
- Stomach Cancer
- Gynecological Cancers
- Immunotherapy
- Hematology
- Haemato-Oncology
- Hormone Therapy
Abstract
Citation: Clin Oncol. 2018;3(1):1505.DOI: 10.25107/2474-1663.1505
The Expression and Prognostic Value of NOX4 in Gastric Cancer
Lu Qiao, Ning Xie, Yuru Bai, Bin Qin, Baicang Zou, Yongquan Shi, Yan Chen, Jinhai Wang and Na Liu
Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, China
Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, China
Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Department of Oncology, Xijing Hospital, the Fourth Military MedicalUniversity, Xi'an, China
*Correspondance to: Jinhai Wang
PDF Full Text Research Article | Open Access
Abstract:
Background: Gastric Cancer (GC) is one of the most common malignant tumors worldwide, while modest progress in diagnosis and treatment of gastric cancer have been made.Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern and prognostic value of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer.Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with including tumor invasion and TNM stage. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer.Conclusion: Our findings proved that NOX4 may be a prognostic factor or therapeutic marker for gastric cancer.
Keywords:
NOX4; Prognostic values; Gastric cancer
Cite the Article:
Qiao L, Xie N, Bai Y, Qin B, Zou B, Shi Y, et al. The Expression and Prognostic Value of NOX4 in Gastric Cancer. Clin Oncol. 2018; 3: 1505.