Histopathologic Features of Endometrial Carcinoma with Fallopian Tube ?nvolvement

Kabukcuoglu S and Yildirim GD

Department of Pathology, University of Osmangazi School of Medicine, Eskisehir, Turkey

^*Correspondance to: Kabukcuoglu S 

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Abstract:

Objectives: Endometrial Carcinoma (EC) is the most common invasive neoplasm in female genital tract. Endometrial cancer occurs in both premenopausal and postmenopausal women. In the large series, 4% to 6% of the cases have diagnosed with the Stage III and Stage IV disease. The reccurences are seen at the same frequency with endometrial cancer cases. Sampling of fallopian tube according to Sectioning and Extensively Examining the Fimbrial End Protocol (SEE-FIM) and examination of dissected lymph nodes and peritoneal washing fluid cytology are necessary for appropriate histopathologic classification of patients. Recent reports indicate that up to 25% of patients with clinically Staged Stage I disease have positive lymph nodes and these cases have microcystic, elongated, and fragmanted glands (MELF). The aim of this study is to document the histopathologic features of endometrial cancer cases with tubal involvement.Methods: Endometrial cancer cases were retrieved from the files of the Pathology Department of Osmangazi University Hospital between the November 2013 and February 2017.Results: A total of 13 endometrial cancer cases with tubal involvement were identified. Positive or suspicious peritoneal washing fluid was observed in three cases. There were three cases that are under 60 years old with superficial myometrial invasion and these cases were associated with endometriosis. In all those cases that are above 60 years old there were deep myometrial invasion and 5 cases had cervical involvement. A total of 7 cases with cervical involvement had not been associated with endometriosis. There was a significant inverse correlation between cervical involvement and endometriosis in the EC cases (P<0.05). Endometriosis was associated with the cases under 60 years old. This correlation was found to be significantly important (P<0.05). The patients having immunohistochemical features of T cell factor/APC/β-cathenin pathway were mostly under 60 years old and this finding was also statistically significant (P<0.05). Among this group two patients had additional abnormalities, which are dual loss of MLH1 and PMS2, and strong p53 positivity. In cases above 60 years old, PTEN inactivation, aging and loss of PAX8 were detected by immunohistochemistry.Conclusion: There is no specific immunohistochemical marker for discrimination of the spilling tubal cells in tubal lumina or peritoneum with the low grade endometrial cancer cells. In this study CK19, P16, WT-1, PAX-8 and calretinin immunohistochemistry were found as useful markers for true classification.

Keywords:

Senescence of fallopian tube; Calretinin signature; Endometrial carcinoma; Stage III; Myoinvasion pattern; Immunohistochemistry

Cite the Article:

Kabukcuoglu S, Yildirim GD. Histopathologic Features of Endometrial Carcinoma with Fallopian Tube ?nvolvement. Clin Oncol. 2018; 3: 1448.