An Overview of Mycotoxins in Human Health with Emphasis on Development and Progression of Liver Cancer

Saurabh Kumar Chhonker, Divya Rawat, Rayees Ahmad Naik and Raj Kumar Koiri

Department of Zoology, Dr. Harisingh Gour Central University, India

^*Correspondance to: Raj Kumar Koiri 

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Abstract:

Contamination of food and feed by mycotoxins has become serious problem worldwide. Contamination of human food with mycotoxin at different stages of food chain has also been observed. Aspergillus, Alternaria, Claviceps, Fusarium, Penicillium and Stachybotrys constitute some of the most important genera of mycotoxins. Amongst them, in recent times due to the genotoxic substance aflatoxin B1 being produced by Aspergillus flavus and Aspergillus parasiticus, food contamination by it has been an area of major concern from the point of view of human health as it is a potent hepatocarcinogenic substance. Along with Aspergillus other mycotoxins are nephrotoxic, nephrocarcinogenic and also affect the reproductive system. Case studies from the last two decade suggest that people living and working in damp and moldy area has greater chances of developing asthma, bronchitis, skin diseases and other health disorder

Keywords:

Aflatoxin; Fungi; Hepatocellular carcinoma; Mycotoxin

Cite the Article:

Chhonker SK, Rawat D, Naik RA, Koiri RK. An Overview of Mycotoxins in Human Health with Emphasis on Development and Progression of Liver Cancer. Clin Oncol. 2018; 3: 1408.