Ján Slezák1*, Juraj Surový2, Jozef Buday2, Branislav Kura
1Institute for Heart Research, Slovak Academy of Sciences, Dúbravskácesta, Bratislava, Slovakia
2Electrotechnical Research and Projecting Company, Trenčianska, Dubnica, Slovakia
Excessive production of oxygen and nitrogen radicals has been regarded as a causative common denominator of many pathological processes. The increase in the rate of radiation-induced heart disease has emphasized the need to seek for new therapeutic targets to mitigate the negative impact of radiation on the heart.Scavenging of free radicals can act preventively or therapeutically. A number of substances that preferentially react with free radicals can serve as scavengers, thus increasing internal capacity/ activity of endogenous antioxidants.Our results demonstrate that in the hearts of rats injured by irradiation H2 administration led to a significant decrease in MDA and TNF-α levels as well as to miRNAs return almost to control levels.Molecular hydrogen (H2) reacts with strong oxidants, such as hydroxyl and nitrosyl radicals in cells, allowing to use its potential for preventive and therapeutic applications in situations with excessive free radicals formation. H2 rapidly diffuses into tissues and cells without affecting signaling reactive species. H2 also reduces oxidative stress by regulating gene expression and functions as an antiinflammatory and anti-apoptotic agent.
Molecular hydrogen; miRNA; ROS; Radiation; Malondialdehyde; Inflammation
Slezák J, Surový J, Buday J, Kura B. Molecular Hydrogen as a Novel Therapeutic Tool in Situations of Increased Production of Free Radicals. Clin Oncol. 2017; 2: 1367.