Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Head and Neck Oncology
  •  Lymphoma
  •  Breast Cancer
  •  Blood Cancer
  •  Neoadjuvant Therapy
  •  Carcinomas
  •  Radiation Therapy
  •  Colon Cancer

Abstract

Citation: Clin Oncol. 2017;2(1):1357.DOI: 10.25107/2474-1663.1357

Effects of Vialinins A and B on Murine Splenocytes Sensitized with Ovalbumin

Jun-ichi Onose, Fumiyo Sekiya, Aki Shiomitsu, Yasukiyo Yoshioka, Kouichi Sugaya and Naoki Abe

Department of Nutritional Science and Food Safety, Faculty of Applied Bio-science, Tokyo University of Agriculture, Japan

*Correspondance to: Naoki Abe 

 PDF  Full Text Research Article | Open Access

Abstract:

Vialinins A and B, as strong inhibitors of the production and release of tumor necrosis factor (TNF)-α, have been isolated from the edible Chinese mush room, Thelephoravialis. Here we investigated the inhibitory effects of vialinins A and B on the immune system. Splenocytes obtained from ovalbumin (OVA)-sensitized BALB/c mice were challenged with OVA in the presence of vialinins A and B, and cytokine levels in the medium of cultured cells were measured. Vialinins A and B inhibited production of OVA-specific immunoglobulin (Ig)E and Th2-type cytokines (interleukin (IL)-4, IL-5, and IL-10) but not production ofTh1-type cytokines (interferon-γ, IL-2, and IL-12). Flow cytometric assay showed a significantly higher percentage of regulatory T cells (CD25- and Foxp3-positive T cells) among splenocytes cultured with OVA and vialinins A and B than among those cultured with OVA alone. This offers a first demonstration that vialinins A and B inhibit antigen-specific IgE- and Th2-type cytokines and regulation of regulatory T cells, suggesting the utility of vialinins A and B in preventing deleterious immune responses.

Keywords:

Cite the Article:

Jun-ichi Onose, Sekiya F, Shiomitsu A, Yoshioka Y, Sugaya K, Abe N. Effects of Vialinins A and B on Murine Splenocytes Sensitized with Ovalbumin. Clin Oncol. 2017; 2: 1357.

Search Our Journal

Journal Indexed In

Articles in PubMed

NMR Metabolomics in Ionizing Radiation
 PubMed  PMC  PDF  Full Text
Metastatic Retroperitoneal Paraganglioma: Case Report and Review of the Literature
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

CEA and CA19-9 Levels and KRAS Mutation Status as Biomarkers for Colorectal Cancer
 Abstract  PDF  Full Text
First Successful Experience of Organ-Preserving Endoscopic Surgical Treatment for Upper Urinary Tract Urothelial Carcinoma
 Abstract  PDF  Full Text
View More...