Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Targeted Therapy
  •  Immunology
  •  Prostate Cancer
  •  Neoadjuvant Therapy
  •  Colon Cancer
  •  Stomach Cancer
  •  Cervical Cancer
  •  Urological Cancers

Abstract

Citation: Clin Oncol. 2017;2(1):1325.DOI: 10.25107/2474-1663.1325

Encapsulation of Doxorubicin in PLGA Nanoparticles Enhances Cancer Therapy

Lakshmi Priya Krishnamoorthy, Rajesh Kannan Moorthy, Devan Umapathy, Mahesh Kumar Kannan, Nithya Ganesan and Antony Joseph Velanganni Arockiam

Department of Biochemistry, School of Life Sciences, Bharathidasan University, India

*Correspondance to: Antony Joseph Velanganni Arockiam 

 PDF  Full Text Review Article | Open Access

Abstract:

The anticancer effect of doxorubicin loaded PLGA nanoparticles on p-Dimethylaminoazobenzene (p-DAB) induced liver cancer in male albino rats has been studied. Nanoparticles of poly (D, L-Lactic-co-glycolic acid) (PLGA) were developed by nanoprecipitation method as delivery system for doxorubicin. Doxorubicin was chemically conjugated to a terminal end group of PLGA. Group I animals were fed with feed and water ad libitum and served as control. Group II-IV animals were received p-DAB intraperitoneal injection at 20 mg/kg body weight once in a week for two months. Then group III animals received intravenous injection of doxorubicin (240 µg/kg body weight) in a tail vein daily. Group IV animals were received intravenous injection of PLGA nanoencapsulated doxorubicin (420 µg of equivalent doxorubicin/kg body weight) in tail vein daily and stopped to the conclusion of the experiment. Doxorubicin loaded PLGA nanoparticles were characterized by X-Ray Diffractometer (XRD), Transmission Electron Microscopy (TEM) and Fourier Transmission InfraRed microscopy (FTIR). The elevated levels of protein, SGOT, SGPT in the p-DAB administered group were significantly reduced by doxorubicin loaded PLGA nanoparticles than free doxorubicin. In vivo anticancer activity showed that administration of doxorubicin loaded PLGA nanoparticles had comparable activity to that of free doxorubicin.

Keywords:

P-dimethylaminoazobenzene; Doxorubicin; Nanoparticles; liver cancer; Poly (D); L-lactic-co-glycolic acid

Cite the Article:

Krishnamoorthy LP, Moorthy RK, Umapathy D, Kannan MK, Ganesan N, Arockiam AJV. Encapsulation of Doxorubicin in PLGA Nanoparticles Enhances Cancer Therapy. Clin Oncol. 2017; 2: 1325.

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