Bindhu Joseph*, K Sruthi and Lokesh Vishwanath
Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, IndiaFulltext PDF
Oesophageal cancer remains a highly lethal malignancy in spite of advances in multimodal approaches that have been adopted in its management during the last two decades. Squamous cell carcinoma of the oesophagus poses an even more difficult entity to treat than adenocarcinoma, on account of its stage at presentation, location and greater propensity for loco-regional recurrence. Oesophageal squamous cell carcinoma shows a relatively high expression of EGFR expression 33- 77%. EGFR (Epidermal Growth Factor Receptor) over expression has been shown to be associated with higher pathological tumour stages, lymph node metastasis as well as poorer disease free survival and overall survival. This review article explores the rationale of Epidermal Growth Factor Receptor targeting in Squamous cell carcinoma of Oesophagus and current clinical data/experience in therapeutically addressing the Epidermal Growth Factor Receptor pathway.
EGFR (Epidermal growth factor receptor); Oesophageal squamous cell carcinoma; Radiation Sensitizer; Targeted therapy
Joseph B, Sruthi K, Vishwanath L. EGFR Targeting in Oesophageal Squamous Cell Carcinoma: Potential Role and Rationale. Clin Oncol. 2017; 2: 1247.