Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Chemoprevention
- Brain and Spinal Cord Cancer
- Colon Cancer
- Immunotherapy
- Endoscopy Methods
- Hematology
- Adjuvant Therapy
- Palliative Care
Abstract
Citation: Clin Oncol. 2017;2(1):1186.DOI: 10.25107/2474-1663.1186
Valproic Acid in Patients with Glioma: A Small Review
Bernardo Cacho-Díaz and Nydia A. Lorenzana-Mendoza
Neuroscience Unit, Instituto Nacional de Cancerología, Mexico
*Correspondance to: Bernardo Cacho-Diaz
PDF Full Text Mini Review | Open Access
Abstract:
Seizures are a well-known and feared manifestation of brain tumors. To some extent, the association between gliomas and the prevalence of seizures correlates inversely with histologic tumor grade. The standard therapy for glioma patients is based on maximal safe resection, followed by temozolomide and radiotherapy. Preclinical studies have proposed a modulatory role of the antiepileptic drug Valproic Acid (VPA) on the efficacy of this treatment increasing overall survival. VPA has shown to: 1) inhibit histone deacetylase increasing the sensitivity of tumor cells to radiation; and 2) have a cytotoxic and proapoptotic role on glioma cells inducing autophagy. We will address the information from studies concerning the use of VPA in patients with glioma.
Keywords:
Cite the Article:
Cacho-Díaz B, Lorenzana-Mendoza NA. Valproic Acid in Patients with Glioma: A Small Review. Clin Oncol. 2017; 2: 1186.
