Uterine Carcinosarcoma after Pelvic Radiotherapy

Chaowawanit W and Tangjitgamo S

Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Thailand

^*Correspondance to: Tangjitgamo S 

 PDF  Full Text Case Report | Open Access

Abstract:

Radiation is a treatment of many gynecologic malignancies, especially locally-advanced cervical cancer. Development of second malignancies is a rare complication of radiotherapy. Our patient had uterine carsinosarcoma20 years after radiotherapy for cervical cancer. Two theories of radiationinduced malignancies were described: direct damage of double strand DNA and the abscopal or indirect damage. No difference in treatment of second cancer (uterine carsinosarcoma) from primary cancer is recommended. However, poor pelvic blood supply form previous radiation may affect tissue healing and the delivery of adjuvant chemotherapy. Our patient had poor prognosis with advanced stage at the time of presentation, rapidly progressed after completion of treatment, and died only 11 months after diagnosis. Uterine carcinosarcoma or malignant mixed mullerian tumor is a biphasic tumor composed of highgrade carcinoma and sarcoma elements [1]. It is a rare gynecological neoplasm (< 5% of all uterine malignancies) [1]. The median ages of diagnosis reported among published series ranged from 62-67 years [2]. The prognosis of uterine carcinosarcoma is poor with a 5-year overall survival of only 30% [3]. Several risk factors for carcinosarcoma were tamoxifen therapy, long-term unopposed estrogen usage, previous radiotherapy, and etc. History of previous pelvic radiotherapy was discovered as high as 37% of carcinosarcoma patients [3]. We reported a patient with advanced-stage uterine carcinosarcoma after a long interval after pelvic radiation for cervical cancer. The clinical, radiographic, pathologic features, management and outcome of the patient were presented.

Keywords:

Cite the Article:

Chaowawanit W, Tangjitgamo S. Uterine Carcinosarcoma after Pelvic Radiotherapy. Clin Oncol. 2016; 1: 1049.